منابع مشابه
Role of Antioxidants in Alzheimer Disease
Oxidative stress is the main cause of impairment of learning and memory. It may occur due to suppression of various brain functions. Antioxidants are therefore very helpful in maintaining the brain functions and improving memory. They are very useful in enhancement of spatial memory also. Various preclinical and clinical studies have been performed on their role in memory enhancement. It has be...
متن کاملLymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease.
CONTEXT A large body of experimental evidence suggests that in Alzheimer disease (AD) pathogenesis an important role is played by oxidative stress, but there is still a lack of data on in vivo markers of free radical-induced damage. OBJECTIVES To evaluate levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative damage to DNA, in peripheral lymphocytes; to measure plasma concentra...
متن کاملDietary Intake of Antioxidants and Risk of Alzheimer Disease
SEVERAL FINDINGS SUGGEST THAT oxidative stress may play an important role in the pathogenesis of Alzheimer disease. First, the brains of patients with Alzheimer disease contain lesions that are typically associated with exposure to free radicals. In addition, oxidative stress in brains of Alzheimer patients is indicated by elevated cerebral levels of endogenous antioxidants that scavenge free r...
متن کاملDietary intake of antioxidants and risk of Alzheimer disease: food for thought.
CONTEXT Laboratory findings have suggested that oxidative stress may contribute to the pathogenesis of Alzheimer disease. Therefore, the risk of Alzheimer disease might be reduced by intake of antioxidants that counteract the detrimental effects of oxidative stress. OBJECTIVE To determine whether dietary intake of antioxidants is related to risk of Alzheimer disease. DESIGN AND SETTING The ...
متن کاملAntioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures.
OBJECTIVE To evaluate whether antioxidant supplements presumed to target specific cellular compartments affected cerebrospinal fluid (CSF) biomarkers. DESIGN Double-blind, placebo-controlled clinical trial. SETTING Academic medical centers. PARTICIPANTS Subjects with mild to moderate Alzheimer disease. INTERVENTION Random assignment to treatment for 16 weeks with 800 IU/d of vitamin E (...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2012
ISSN: 0003-9942
DOI: 10.1001/archneurol.2012.85